2012 Distinguished Achievement Award Winner

Avrum Gotlieb MDCM, FRCPC

Gaetano Thiene

Prof. Gotlieb is the Senior Academic Advisor to the Dean (2011-2013), and Acting Vice-Dean, Graduate Affairs (2011-2013) in the Faculty of Medicine, University of Toronto. He obtained his BSc, MDCM and his Anatomic Pathology training at McGill University. He trained in the Department of Biology, University of California, San Diego, with S.J. Singer. Prof. Gotlieb joined the Department of Pathology at the University of Toronto in 1978. He is a cardiovascular pathologist at the University Health Network and a senior scientist at the Toronto General Research Institute. Prof. Gotlieb served as the founding Chair of the Department of Laboratory Medicine and Pathobiology (1997-2008), and as Interim Vice-Dean Research and International Relations (2009-2010) in the Faculty of Medicine, University of Toronto.

Prof. Gotlieb has received teaching awards from the hospital, the department, Faculty of Medicine, including two prestigious Aikins Awards and the Sustained Excellence in Graduate Teaching Award, as well as the Robbins Distringuished Educator Award from the American Society for Investigative Pathology (2011). He initiated an innovative and unique undergraduate arts and science specialist program in pathobiology that is in its 10th year and has seen many of its graduates go on to graduate and medical school. Prof Gotlieb authored the widely-disseminated informative career guide booklet, "The Road to Becoming a Biomedical Physician Scientist in Pathology and Laboratory Medicine," sponsored by the American Society of Investigative Pathology and the Department of Laboratory Medicine & Pathobiology, University of Toronto, and in 2009 co-authored (with Dr. Tara Sander) a second career guide booklet for ASIP, "Journey to Success: Career Pathways for Biomedical Scientists in Pathology and Laboratory Medicine.”

Prof. Gotlieb’s research includes atherosclerosis and valvular heart disease. Studies on the cell biology of cardiac valves focus on the role of interstitial valvular cells in maintaining the structure and function of heart valves, and interstitial cell function related to repair and cell heterogeneity. In vitro studies on endothelial injury and repair directed at understanding how the cell cytoskeleton regulates cell migration, and how various growth factors and cytokines modulate both migration and proliferation related to repair. Earlier studies include the pathogenesis of intimal hyperplasia, a lesion that predisposes to fibrofatty plaque formation; and the role of growth factors, cytokines, and proteinases on intimal hyperplasia. He has published over 100 peer-reviewed papers, and 37 reviews and book chapters. He has edited three books, including the comprehensive textbook Cardiovascular Pathology, edited with colleagues Malcolm D. Silver of the University of Toronto, and Frederick J. Schoen of Harvard Medical School. He has been an invited visiting professor and keynote speaker at national and international universities and research institutes. He is co-editor of the journal Cardiovascular Pathology (2001-2011) and serves on the editorial board of several leading journals in pathology, the American Journal of Pathology and Laboratory Investigation.

Prof. Gotlieb has been an innovative leader in academic medicine creating national and international infrastructures to promote research and education. His focus has been on Pathology and Laboratory Medicine and Cardiovascular Pathology. He has provided guidance through carrying out external academic reviews, leading grant review panels and lecturing on the academic missions of Pathology and Laboratory Medicine. He is a past-president of the Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology, the Society for Cardiovascular Pathology and the American Society for Investigative Pathology. He is past vice-president for science policy of the Federation of American Societies for Experimental Biology, Bethesda, MD. In 2006, Prof. Gotlieb was elected as a fellow of the Canadian Academy of Health Sciences, and will be awarded the Distinguished Achievement Award from the Society for Cardiovascular Pathology (2012).